Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production

Revista Brasileira de Farmacognosia

Carli, Camila B. A.¹  Watanabe, Márcio¹  São Paulo State University, Araraquara, Brazil¹  Micheletti, Ana C.¹  Vilegas, Wagner¹  São Paulo State University, Brazil¹  Honda, Neli K.¹  Lopes, Flavia C. M.¹  Santos, Lourdes C. dos¹  Carlos, Iracilda Z.¹  Maia, Danielle C. G.¹  Benzatti, Fernanda P.¹  Roese, Fernanda M.¹  Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil¹ 

关键词: lichens;    hydrogen peroxide;    nitric oxide;    macrophages;    phenolic compounds.;   

DOI  :  10.1590/S0102-695X2009000600009

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The effects of isolated compounds from Brazilian lichens and their derivatives on H2O2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H2O2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H2O2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.

【 授权许可】

Unknown