Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents

Revista Brasileira de Farmacognosia

Rafael R. B. Oliveira²  Rebecca M. O. Góis¹  Rosana S. Siqueira²  Jackson R. G. S. Almeida¹  Julianeli T. Lima¹  Xirley P. Nunes¹  Viseldo R. Oliveira¹  Jullyana S. Siqueira²  Lucindo J. Quintans-júnior² 

[1] ,Universidade Federal de Sergipe Departamento de Fisiologia São Cristóvão SE ,Brazil

关键词: Amburana cearensis;    Fabaceae;    antinociceptive activity;    medicinal plant;    Amburana cearensis;    Fabaceae;    atividade antinociceptiva;    plantas medicinais;   

DOI  :  10.1590/S0102-695X2009000500004

来源: SciELO

【 摘 要 】

The ethanolic extract of the trunk bark of Amburana cearensis (EEA) was examined for its oral (p.o.) analgesic activity at the doses of 100, 200 and 400 mg/kg body weight. In the acetic acid-induced writhing test, the EEA (200 and 400 mg/kg, p.o.) reduced the number of writhing by 33.4% and 40.7%, respectively. Additionally, EEA (100, 200 and 400 mg/kg, p.o.) decreased by 77.5%, 79.7 and 91.3%, respectively, the paw liking time in the second phase of the formalin test. Therefore, EEA showed a dose-dependent analgesic effect in formalin test and was effective in reducing writhing in mice.

【 授权许可】

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