Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents

Revista Brasileira de Farmacognosia

Oliveira, Rafael R. B.¹  Universidade Federal de Sergipe, São Cristóvão, Brazil¹  Lima, Julianeli T.¹  Almeida, Jackson R. G. S.¹  Empresa Brasileira de Pesquisa Agropecuária, Petrolina, Brazil¹  Góis, Rebecca M. O.¹  Oliveira, Viseldo R.¹  Quintans-Júnior, Lucindo J.¹  Siqueira, Jullyana S.¹  Nunes, Xirley P.¹  Siqueira, Rosana S.¹  Universidade Federal do Vale do São Francisco, Petrolina, Brazil¹ 

关键词: Amburana cearensis;    Fabaceae;    antinociceptive activity;    medicinal plant.;   

DOI  :  10.1590/S0102-695X2009000500004

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The ethanolic extract of the trunk bark of Amburana cearensis (EEA) was examined for its oral (p.o.) analgesic activity at the doses of 100, 200 and 400 mg/kg body weight. In the acetic acid-induced writhing test, the EEA (200 and 400 mg/kg, p.o.) reduced the number of writhing by 33.4% and 40.7%, respectively. Additionally, EEA (100, 200 and 400 mg/kg, p.o.) decreased by 77.5%, 79.7 and 91.3%, respectively, the paw liking time in the second phase of the formalin test. Therefore, EEA showed a dose-dependent analgesic effect in formalin test and was effective in reducing writhing in mice.

【 授权许可】

Unknown