In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants

Revista Brasileira de Farmacognosia

Fernando R. Pavan²  Daisy N. Sato¹  Célio T. Higuchi²  Adolfo C. B. Santos²  Wagner Vilegas¹  Clarice Q. E Leite² 

[1] ,Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Ciências Farmacêuticas Departamento de Ciências BiológicasAraraquara SP ,Brazil

关键词: Brazilian "Cerrado" plants;    Mycobacterium tuberculosis;    antitubercular activity;    MABA;    Plantas do Cerrado Brasileiro;    Mycobacterium tuberculosis;    atividade anti-tuberculose;    MABA;   

DOI  :  10.1590/S0102-695X2009000200004

来源: SciELO

【 摘 要 】

The aim of this work was to carry out a screening of some plants of this Brazilian region with activity against Mycobacterium tuberculosis. Chloroform and methanol extracts of 37 plant species distributed among 17 families from Brazilian "Cerrado" which were tested against M. tuberculosis H37Rv and the Minimum Inhibitory Concentration (MIC) was determined by the use of Microplate Alamar Blue Assay (MABA). Crude extracts from sixteen plants showed MIC value of < 125 µg/mL and three 31.2 µg/mL. These results suggest that the Brazilian "Cerrado" may be a source of plants that have activity anti-M. tuberculosis constituents that can be extracted by polars and apolars solvents.

【 授权许可】

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