Bioactivity of two Turkish endemic Centaurea species, and their major constituents

Revista Brasileira de Farmacognosia

Mohammad Shoeb²  Stephen M. Macmanus¹  Marcel Jaspars¹  Paul Kong-thoo-lin¹  Lutfun Nahar¹  Sezgin Celik¹  Satyajit D. Sarker¹ 

[1] ,University of Dhaka Department of Chemistry ,Bangladesh

关键词: Centaurea urvillei subs. armata;    Centaurea mucronifera;    Asteraceae;    Compositae;    lignan;    arctiin;    matairesinoside;    DPPH;    MTT;    brine shrimp lethality assay;    Centaurea urvillei subs. armata;    Centaurea mucronifera;    Asteraceae;    Compositae;    lignana;    arctiina;    matairesinosídeo;    DPPH;    MTT;    Artemia salina;    toxicidade;   

DOI  :  10.1590/S0102-695X2007000200003

来源: SciELO

【 摘 要 】

The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs. armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol extracts afforded two bioactive dibenzylbutyrolactone-type lignans, matairesinoside (1) and arctiin (2). The structures of these lignans were elucidated by comprehensive spectroscopic analyses as well as by the direct comparison of experimental data with respective literature data.

【 授权许可】

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