Bioactivity of two Turkish endemic Centaurea species, and their major constituents

Revista Brasileira de Farmacognosia

Canakkale Onsekiz Mart University, Turkey¹  Shoeb, Mohammad¹  University of Ulster, Northern Ireland, UK¹  The Robert Gordon University, UK¹  MacManus, Stephen M.¹  Kong-Thoo-Lin, Paul¹  Nahar, Lutfun¹  University of Aberdeen, UK¹  University of Dhaka, Bangladesh¹  Jaspars, Marcel¹  Celik, Sezgin¹  Sarker, Satyajit D.¹ 

关键词: Centaurea urvillei subs. armata;    Centaurea mucronifera;    Asteraceae;    Compositae;    lignan;    arctiin;    matairesinoside;    DPPH;    MTT;    brine shrimp lethality assay.;   

DOI  :  10.1590/S0102-695X2007000200003

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs. armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol extracts afforded two bioactive dibenzylbutyrolactone-type lignans, matairesinoside (1) and arctiin (2). The structures of these lignans were elucidated by comprehensive spectroscopic analyses as well as by the direct comparison of experimental data with respective literature data.

【 授权许可】

Unknown