Effect of the activity of the Brazilian polyherbal formulation: Eucalyptus globulus Labill, Peltodon radicans Pohl and Schinus terebinthifolius Radd in inflammatory models

Revista Brasileira de Farmacognosia

Karina C.p. Medeiros¹  Juliana C. Monteiro¹  Margareth F.f.m. Diniz¹  Isac A. Medeiros¹  Bagnólia A. Silva¹  Márcia R. Piuvezam¹ 

[1] ,Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica Prof. Delby F. de Medeiros João Pessoa PB ,Brazil

关键词: Brazilian polyherbal formulation;    anti-inflammatory activity;    capsaicin;    12-O-tetradecanoylphorbol 13-acetate;    Medicamento fitoterápico brasileiro;    atividade antiinflamatória;    capsaicina;    12-O-tetradecanoilforbol 13-acetato;   

DOI  :  10.1590/S0102-695X2007000100006

来源: SciELO

【 摘 要 】

The Brazilian polyherbal formulation (BPF) is composed by dyes of Eucalyptus globulus Labill, Peltodon radicans Pohl and Schinus terebinthifolius Raddi in alcohol at 13.3° GL. The formulation is popularly used in Paraíba state, Brazil since 1889 and it is used as an antiseptic and anti-inflammatory medicine. The aim of this study was to evaluate the anti-inflammatory property of the polyherbal formulation. For this purpose it was used the12-O-tetradecanoylphorbol 13-acetate (TPA) and capsaicin-induced mouse ear edema and the carrageenan-induced rat paw edema. The BPF at dose of 26 mL/Kg inhibited both 12-O-tetradecanoylphorbol 13-acetate (TPA) and capsaicin-induced ear edema by 49% (p < 0.05) and 24% (p < 0.01) respectively. Preliminary results on carrageenan-induced rat paw edema demonstrated that oral administration also inhibited the paw edema by approximately 29%. The results demonstrate that the Brazilian polyherbal formulation has anti-inflammatory activity and the better dose was the one used by the population.

【 授权许可】

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