Comparison of serum creatinine levels in different color/race categories in a Brazilian population

Cadernos de Saúde Pública

Roberto Carlos De Brito Barcellos¹  Jorge Paulo Strogoff De Matos¹  Hye Chung Kang¹  Maria Luiza Garcia Rosa¹  Jocemir Ronaldo Lugon¹ 

关键词: Creatinine;    Glomerular Filtration Rate;    Ethnicity and Health;    Creatinina;    Taxa de Filtração Glomerular;    Origem Étnica e Saúde;    Creatinina;    Tasa de Filtración Glomerular;    Origen Étnico y Salud;   

DOI  :  10.1590/0102-311X00150814

来源: SciELO

【 摘 要 】

Serum creatinine (sCr) is usually higher among black people in the United States due to increased muscle mass, justifying the addition of race adjustment in creatinine-based formulas to estimate glomerular filtration rate (eGFR). We aimed to assess if sCr levels are different in low-income communities in Brazil according to their race. A total of 1,303 participants were enrolled (58% females, 50±14 years-old, 33% self-defined as white, 41% as mixed race, and 26% as black). No significant differences in sCr were found between racial groups and no influence of race on sCr was seen in the linear regression analysis. The eGFR, calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula with no race adjustment, was no different between whites, mixed race and blacks. However, using such adjustment, eGFR for mixed race and black individuals was significantly higher than for whites (p < 0.001). In conclusion, no significant differences in sCr levels were found between racial groups, raising doubts as to whether race adjustment in eGFR formula should be used in that population.

【 授权许可】

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