First reported outbreak of green tobacco sickness in Brazil

Cadernos de Saúde Pública

Patricia Pereira Vasconcelos De Oliveira²  Camila Brederode Sihler²  Lenildo De Moura²  Deborah Carvalho Malta²  Maria Célia De Albuquerque Torres¹  Sandra Márcia Da Costa Pereira Lima¹  Ana Lucia Alves De Lima¹  Carlos Eduardo Leite¹  Vera Luiza Da Costa-e-silva¹  Jeremy Sobel²  Tatiana Miranda Lanzieri² 

[1],Ministério da SaúdeBrasília,Brasil

关键词: Tobacco;    Nicotine;    Occupational Diseases;    Agriculture;    Tabaco;    Nicotina;    Doenças Profissionais;    Agricultura;   

DOI  :  10.1590/S0102-311X2010001200005

来源: SciELO

【 摘 要 】

Dermal absorption of nicotine by people harvesting tobacco may cause an acute intoxication called green tobacco sickness. Although Brazil is the second largest producer of tobacco in the world, green tobacco sickness had not been reported in the country to date. We conducted a 1:1 matched case-control study among persons involved in tobacco farming to determine the occurrence of green tobacco sickness in the northeast region of Brazil and to identify the risk factors involved. A case-patient was a person who received a diagnosis by health professional of acute intoxication during the study period and had a cotinine level over 10ng/mL detected by High Performance Liquid Chromatography. We identified 107 case-patients. The main signs and symptoms observed were dizziness, weakness, vomit, nausea and headache. Independent risk factors identified were being male, a non smoker and having worked in the harvest of tobacco leaves. Case-patients had higher median urinary cotinine levels than controls (p < 0.05). Epidemiological and laboratory data indicate for the first time the occurrence of green tobacco sickness in Brazil.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License