Impact of methodology on the results of economic evaluations of varicella vaccination programs: is it important for decision-making?

Cadernos de Saúde Pública

Patrícia Coelho De Soárez¹  Hillegonda Maria Dutilh Novaes¹  Ana Marli Christovan Sartori¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina São Paulo,Brasil

关键词: Cost-Effectiveness Evaluation;    Costs and Cost Analysis;    Immunization Programs;    Chickenpox;    Avaliação de Custo-Efetividade;    Custos e Análise de Custo;    Programas de Imunização;    Varicela;   

DOI  :  10.1590/S0102-311X2009001500006

来源: SciELO

【 摘 要 】

This study aims to review the literature on economic evaluation of childhood varicella vaccination programs and to discuss how heterogeneity in methodological aspects and estimation of parameters can affect the studies' results. After applying the inclusion criteria, 27 studies published from 1980 to 2008 were analyzed in relation to methodological differences. There was great heterogeneity in the perspective adopted, evaluation of indirect costs, type of model used, modeling of the effect on herpes zoster, and estimation of vaccine price and efficacy parameters. The factor with the greatest impact on results was the inclusion of indirect costs, followed by the perspective adopted and vaccine price. The choice of a particular methodological aspect or parameter affected the studies' results and conclusions. It is essential that authors present these choices transparently so that users of economic evaluations understand the implications of such choices and the direction in which the results of the analysis were conducted.

【 授权许可】

CC BY   
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