Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials

Cadernos de Saúde Pública

Ariani Impieri De Souza²  Malaquias Batista Filho²  Cristiane Campello Bresani²  Luiz Oscar Cardoso Ferreira¹  José Natal Figueiroa² 

[1] ,Instituto de Medicina Integral Professor Fernando FigueiraRecife,Brasil

关键词: Anemia;    Iron Deficiency;    Ferrous Sulfate;    Pregnant Women;    Anemia;    Deficiência de Ferro;    Sulfato Ferroso;    Gestantes;   

DOI  :  10.1590/S0102-311X2009000600005

来源: SciELO

【 摘 要 】

The objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License