Treament and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial

Cadernos de Saúde Pública

Maria Claret Costa Monteiro Hadler²  Dirce Maria Sigulem¹  Maria De Fátima Costa Alves¹  Vinícius Montenegro Torres¹ 

[1] ,Universidade Federal de Goiás Faculdade de Nutrição Goiânia,Brasil

关键词: Nutritional Epidemiology;    Anemia;    Ferrous Sulfate;    Folic Acid;    Child Day Care Centers;    Epidemiologia Nutricional;    Anemia;    Sulfato Ferroso;    Ácido Fólico;    Creches;   

DOI  :  10.1590/S0102-311X2008001400011

来源: SciELO

【 摘 要 】

The objective of this study was to assess the prevalence of anemia and the therapeutic and prophylactic response to ferrous sulfate and folic acid. A double-blind, randomized, controlled clinical trial was conducted with 196 children 6 to 24 months of age enrolled in municipal daycare centers in Goiânia, Goiás State, Brazil. The children were assigned to two treatment groups that received a daily dose (5 times a week) of either 4.2mg/kg/day of ferrous sulfate + folic acid (50µg) or 4.2mg/kg/day of ferrous sulfate + folic acid placebo. One of the prevention groups received 1.4mg/kg/day of ferrous sulfate + folic acid (50µg/day) and the other 1.4mg/kg/day of ferrous sulfate + folic acid placebo. Supplementation lasted approximately three months. Baseline anemia prevalence was 56.1% (95%CI: 48.9-63.1). After treatment, anemia prevalence in the folic acid group (14%) was lower than in the placebo group (34.9%) (p = 0.02). After prophylaxis in the non-anemic children, the incidence of anemia did not differ between the groups, but there was an increase in hemoglobin level in the folic acid group (p = 0.003). Iron plus folic acid was effective for the treatment of anemia and improvement of hemoglobin level in non-anemic children.

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