Exposure to misoprostol and hormones during pregnancy and risk of congenital anomalies

Cadernos de Saúde Pública

Tatiane Da Silva Dal Pizzol²  Maria Teresa Vieira Sanseverino¹  Sotero Serrate Mengue¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Porto Alegre,Brasil

关键词: Misoprostol;    Hormones;    Abnormalities;    Women's Health;    Misoprostol;    Hormônios;    Anormalidades;    Saúde da Mulher;   

DOI  :  10.1590/S0102-311X2008000600025

来源: SciELO

【 摘 要 】

This study evaluated the association between use of misoprostol and other drugs to induce menstruation, and congenital anomalies. A sample of 4,856 pregnant women 20 years and older were enrolled consecutively in prenatal services in the Unified National Health System, in six Brazilian State capitals. Data on socio-demographics and use of medicines were obtained using an interview from the 21st to 28th week of pregnancy. Other data, including information on delivery and diagnosis of congenital anomalies by the attending neonatal physician were obtained from patient charts. Potential confounders were adjusted by logistic regression. Use of drugs to induce menstruation was reported by 707 women (14.6%), of whom 120 (17%) reported use of misoprostol. After adjusting for the study center, a positive association was observed between misoprostol and congenital anomalies (OR = 2.64; 95%CI: 1.03-6.75); a positive association was also observed for sex hormones (OR = 2.24; 95%CI: 1.06-4.74). The results suggest that the use of misoprostol or sex hormones during pregnancy increases the risk of congenital anomalies.

【 授权许可】

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