Serum lipid profile and hepatic evaluation in mice fed diet containing pequi nut or pulp (Caryocar brasiliense Camb.)

Food Science and Technology (Campinas)

Edenil Costa Aguilar²  Maria Das Graças Mota Nobre Queiroz¹  Dario Alves De Oliveira¹  Neide Judith Faria De Oliveira¹ 

[1] ,Universidade Federal de Minas Gerais Departamento de Bioquímica e Imunologia Laboratório de Aterosclerose e Bioquímica NutricionalBelo Horizonte MG ,Brasil

关键词: lipids;    diet;    atherosclerosis;    monounsaturated fatty acid;    lipídios;    dieta;    aterosclerose;    ácidos graxos monoinsaturados;   

DOI  :  10.1590/S0101-20612011000400008

来源: SciELO

【 摘 要 】

Caryocar brasiliense (popular name pequi) is widely consumed by the population of Brazilian Savannah. This fruit has a high concentration of monounsaturated fatty acids that can influence positively the lipid profile. In addition, pequi also has an important concentration of saturated fatty acids which, in turn, is associated with atherosclerosis risk. This study aimed to investigate the effect of a pequi-supplemented diet on blood lipid and glucose levels and hepatic histology. Female Albino swiss mice were divided into three groups and fed a standard chow diet (control group), chow diet supplemented with 33% pequi nut (nut group), and chow diet supplemented with 33% pequi pulp (pulp group). After 6 weeks, following an overnight fast, blood and liver were collected for posterior analyses. Serum total cholesterol and HDL-cholesterol were significantly higher in mice fed pequi-rich diets compared to the control group. Nevertheless, there was no modification in blood triglycerides, atherogenic fraction, and glucose levels. In addition, there was development of liver microvesicular steatosis related to pequi intake. In conclusion, the diets supplemented with pequi nut or pulp reduced the atherogenic risk by increasing the anti-atherogenic lipoproteins without changing the pro-atherogenic fraction in mice.

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