Brazilian Journal of Medical and Biological Research | |
Nitro-fatty acids: novel anti-inflammatory lipid mediators | |
H. Rubbo1  | |
关键词: Nitro-fatty acids; Antioxidants; Nitric oxide; Inflammation; | |
DOI : 10.1590/1414-431X20133202 | |
来源: SciELO | |
【 摘 要 】
Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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RO202005130079084ZK.pdf | 793KB | download |