Nitro-fatty acids: novel anti-inflammatory lipid mediators

Brazilian Journal of Medical and Biological Research

H. Rubbo¹ 

关键词: Nitro-fatty acids;    Antioxidants;    Nitric oxide;    Inflammation;   

DOI  :  10.1590/1414-431X20133202

来源: SciELO

【 摘 要 】

Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License