Brazilian Journal of Medical and Biological Research | |
Mechanisms of endothelial dysfunction in obesity-associated hypertension | |
N.s. Lobato2  F.p. Filgueira2  E.h. Akamine2  R.c. Tostes1  M.h.c. Carvalho2  Z.b. Fortes2  | |
[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de FarmacologiaSão Paulo SP ,Brasil | |
关键词: Hypertension; Obesity; Endothelial dysfunction; Oxidative stress; Renin-angiotensin system; Nitric oxide; | |
DOI : 10.1590/S0100-879X2012007500058 | |
来源: SciELO | |
【 摘 要 】
Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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