Mechanisms of endothelial dysfunction in obesity-associated hypertension

Brazilian Journal of Medical and Biological Research

N.s. Lobato²  F.p. Filgueira²  E.h. Akamine²  R.c. Tostes¹  M.h.c. Carvalho²  Z.b. Fortes² 

[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de FarmacologiaSão Paulo SP ,Brasil

关键词: Hypertension;    Obesity;    Endothelial dysfunction;    Oxidative stress;    Renin-angiotensin system;    Nitric oxide;   

DOI  :  10.1590/S0100-879X2012007500058

来源: SciELO

【 摘 要 】

Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension.

【 授权许可】

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