Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease

Brazilian Journal of Medical and Biological Research

G.a. Dosreis¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho Rio de Janeiro RJ ,Brasil

关键词: Trypanosoma cruzi;    T cells;    GPI-anchors;    TGF-β;    Mucin;    Apoptosis;   

DOI  :  10.1590/S0100-879X2011007500005

来源: SciELO

【 摘 要 】

Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed.

【 授权许可】

CC BY   
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