Brazilian Journal of Medical and Biological Research | |
The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal | |
V. Benetello2  F.c. Sakamoto2  F.p.m. Giglio2  V.t. Sakai1  A.m. Calvo2  K.c.s. Modena2  B.l. Colombini2  T.j. Dionísio2  J.r.p. Lauris1  F.a.c. Faria2  C.f. Santos2  | |
[1] ,Universidade de São Paulo Faculdade de Odontologia de Bauru Departamento de Ciências Biológicas | |
关键词: Acute postoperative pain; Cyclooxygenase inhibitors; Lower third molar; Non-steroidal anti-inflammatory drugs; Piroxicam; Valdecoxib; | |
DOI : 10.1590/S0100-879X2006005000123 | |
来源: SciELO | |
【 摘 要 】
We compared the clinical efficacy of orally administered valdecoxib and piroxicam for the prevention of pain, trismus and swelling after removal of horizontally and totally intrabony impacted lower third molars. Twenty-five patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Valdecoxib (40 mg) or piroxicam (20 mg) was administered in a double-blind, randomized and crossed manner for 4 days after the surgical procedures. Objective and subjective parameters were recorded for comparison of postoperative courses. Both agents were effective for postoperative pain relief (N = 19). There was a similar mouth opening at suture removal compared with the preoperative values (86.14 ± 4.36 and 93.12 ± 3.70% of the initial measure for valdecoxib and piroxicam, respectively; ANOVA). There was no significant difference regarding the total amount of rescue medication taken by the patients treated with valdecoxib or piroxicam (173.08 ± 91.21 and 461.54 ± 199.85 mg, respectively; Wilcoxon test). There were no significant differences concerning the swelling observed on the second postoperative day compared to baseline measures (6.15 ± 1.84 and 8.46 ± 2.04 mm for valdecoxib and piroxicam, respectively; ANOVA) or on the seventh postoperative day (1.69 ± 1.61 and 2.23 ± 2.09 mm for valdecoxib and piroxicam, respectively; ANOVA). The cyclooxygenase-2 selective inhibitor valdecoxib is as effective as the non-selective cyclooxygenase inhibitor piroxicam for pain, trismus and swelling control after removal of horizontally and totally intrabony impacted lower third molars.
【 授权许可】
CC BY
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