A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat

Brazilian Journal of Medical and Biological Research

A.m.m. Bonilha¹  R.m. Saraiva¹  R.m. Kanashiro¹  L.a. Portes¹  E.l. Antonio¹  P.j.f. Tucci¹ 

[1] ,Universidade Federal de São Paulo Laboratório de Fisiologia Cardíaca São Paulo SP ,Brasil

关键词: Myocardial infarction size;    Rats;    Electrocardiogram;    Echocardiogram;    ROC curve;   

DOI  :  10.1590/S0100-879X2005000400016

来源: SciELO

【 摘 要 】

Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed focusing on MI size, none of these current electrocardiographic indices of MI size adequately discriminates LMI from SMI.

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