Brazilian Journal of Medical and Biological Research | |
Comparative study of IgA nephropathy with and without crescents | |
C. Bitencourt-dias2  M. Bahiense-oliveira2  L.b. Saldanha1  R.t. Barros2  V. Woronik2  | |
[1] ,Universidade de São Paulo Hospital das Clínicas Disciplina de Nefrologia | |
关键词: IgA nephropathy; Crescents; Renal failure; End-stage renal disease; Creatinine; | |
DOI : 10.1590/S0100-879X2004000900012 | |
来源: SciELO | |
【 摘 要 】
Glomerular crescents were analyzed as a prognostic factor in retrospectively reviewed data from 144 patients with biopsy-proven IgA nephropathy. Crescents were found in 26 (18%) patients, and detected in 2 to 100% of glomeruli in each specimen. In 5% of the patients more than 50% of the glomeruli were affected. Thirty patients with IgA nephropathy without crescents were studied as a control group. Mean age was 30.3 ± 9.4 and 30.2 ± 12.0 years for the patients with and without crescents, respectively, and males prevailed in both groups. The length of follow-up was 23.2 ± 41.6 months for patients with crescents and 29.3 ± 35.3 months for patients without crescents. Eighty percent of the patients with crescents were hypertensive, compared to 27% of the non-crescent control group (P < 0.05). Mean serum creatinine at the time of diagnosis was 3.9 ± 2.9 and 1.9 ± 2.1 mg/dl for the patients with and without crescents, respectively. Initial urinary protein excretion was higher in patients with crescents (4.6 ± 3.5 vs 1.2 ± 0.9 g/day; P < 0.05). At the end of follow-up 17 patients (77.3%) from the crescent group and 3 (11.1%) from the non-crescent group had end-stage renal disease (P < 0.0001). The presence of crescents was associated with higher levels of initial serum creatinine and urinary protein excretion, and a higher frequency of hypertension and progression to end-stage renal disease.
【 授权许可】
CC BY
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