Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning

Brazilian Journal of Medical and Biological Research

M.g.m. Oliveira¹  O.f.a. Bueno¹  E.b. Gugliano¹ 

[1] ,Universidade Federal de São Paulo

关键词: electroconvulsive shock;    memory;    cued fear conditioning;    inhibitory avoidance;    anxiolytic effect;    analgesic effect;   

DOI  :  10.1590/S0100-879X1998000800009

来源: SciELO

【 摘 要 】

A single electroconvulsive shock (ECS) or a sham ECS was administered to male 3-4-month-old Wistar rats 1, 2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment). ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned stimulus (CS)-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairment is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration) and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus.

【 授权许可】

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