Idiopathic focal segmental glomerulosclerosis and HLA antigens

Brazilian Journal of Medical and Biological Research

M. Gerbase-delima¹  A. Pereira-santos²  R. Sesso²  J. Temin¹  E.s. Aragão¹  H. Ajzen² 

关键词: focal segmental glomerulosclerosis;    genetics;    HLA antigens;    MHC;   

DOI  :  10.1590/S0100-879X1998000300010

来源: SciELO

【 摘 要 】

The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS). HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2%, P<0.05). In addition, the three patients of Japanese extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further evidence for a role of genes of the HLA complex in the susceptibility to this disease

【 授权许可】

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