Multifactorial control of water and saline intake: role of a2-adrenoceptors

Brazilian Journal of Medical and Biological Research

L.a. De-luca Jr.¹  J.v. Menani¹ 

关键词: sodium intake;    water intake;    clonidine;    noradrenaline;    dehydration;    a 2-adrenergic agonist;   

DOI  :  10.1590/S0100-879X1997000400011

来源: SciELO

【 摘 要 】

Water and saline intake is controlled by several mechanisms activated during dehydration. Some mechanisms, such as the production of angiotensin II and unloading of cardiovascular receptors, activate both behaviors, while others, such as the increase in blood osmolality or sodium concentration, activate water, but inhibit saline intake. Aldosterone probably activates only saline intake. Clonidine, an a2-adrenergic agonist, inhibits water and saline intake induced by these mechanisms. One model to describe the interactions between these multiple mechanisms is a wire-block diagram, where the brain circuit that controls each intake is represented by a summing point of its respective inhibiting and activating factors. The a2-adrenoceptors constitute an inhibitory factor common to both summing points

【 授权许可】

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