Central lead administration inhibits water intake and sodium appetite in rats

Brazilian Journal of Medical and Biological Research

E.j. De-castro-e-silva²  L. Castro²  C.p. Luz²  H. Ferreira²  A.k.s. Lima²  F.s.f. Souza²  I. Maldonado²  D.f. Macêdo²  M.g. Ferreira²  I.p.v. Bandeira¹  A.l.m. Amor¹  F.l.q. Carvalho²  M.a. Rocha Jr.²  J.b. Fregoneze¹ 

[1] ,Universidade Federal da Bahia

关键词: lead;    angiotensin II;    water intake;    sodium intake;    rats;   

DOI  :  10.1590/S0100-879X1999001000011

来源: SciELO

【 摘 要 】

We have demonstrated that acute third ventricle injections of lead acetate (PbAc) exert a powerful antidipsogenic effect and induce a significant increase in renal sodium excretion. In the present study we confirm the antidipsogenic effect of lead and demonstrate that central administration of this metal, in minute amounts, significantly reduces salt intake both during dehydration and after central angiotensinergic stimulation. Adult male Wistar rats had the third ventricle cannulated seven days before the experiments. During this period they had free access to distilled water and hypertonic saline solution (1.5%). After a 24-h period of fluid deprivation, experimental animals received third ventricle injections of PbAc (0.3, N = 8 and 3.0 nmol/rat, N = 14) while controls received sodium acetate (NaAc; 3.0 nmol/rat, N = 10). Rats treated with PbAc at the highest dose showed a significant reduction (P<0.05) both in water and hypertonic saline intake when compared to controls. When the effect of lead administration on angiotensin II-induced water and salt intake was studied, normohydrated animals received third ventricle injections of angiotensin II (9.6 nmol/rat) after pretreatment with 3.0 nmol/rat of PbAc (experimental group, N = 10) or NaAc (controls, N = 8). The group pretreated with PbAc presented a significant reduction (P<0.05) in both water and salt intake compared to controls. Thus, this study confirms the antidipsogenic effect of central lead injections and demonstrates that the presence of lead in the brain exerts a significant inhibition of sodium appetite.

【 授权许可】

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