Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

Pesquisa Veterinária Brasileira

Alessandra S. Lima¹  Rebeca A. Weigel¹  Aline A. Morgado¹  Giovanna R. Nunes¹  Fernando N. Souza¹  Andrea M. Moreno¹  Alice Maria M.p. Della Libera¹  Maria Claudia A. Sucupira¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de Clínica MédicaSão Paulo SP ,Brazil

关键词: Immune response;    weaning;    piglets;    GSH;    MSD and SOD;    Resposta imune;    desmame;    leitões;    GSH;    MDA e SOD;   

DOI  :  10.1590/S0100-736X2012000800008

来源: SciELO

【 摘 要 】

The weaning period of piglets is characterized by physiological alterations, such as decreased weight gain, increased reactive oxygen species (ROS) and increased serum cortisol levels with possible effects on the immune response. The effect of parenteral administration of vitamins A, D and E on production performance, oxidative metabolism, and the function of polymorphonuclear leukocytes (PMNLs) was assessed in piglets during the weaning period. The sample was comprised of 20 male piglets that were given an injectable ADE vitamin combination (135,000 IU vitamin A, 40,000 IU vitamin D and 40mg vitamin E/ animal) at 20 and 40 days of age. Weight gain, concentration of reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) and the microbicidal and phagocytic activity of PMNLs were assessed. No difference was observed in the average piglet weight during the study; however, a greater percentage of weight gain was observed after weaning in the treated group. The concentrations of GSH and SOD did not differ between groups, although lipid peroxidation was greater in the control group at 60 days of age. The investigated variables of oxidative metabolism were correlated as follows: -0.41 for GSH and MDA, -0.54 for GSH and SOD and 0.34 for MDA and SOD. The intensity of intracellular ROS production, the percentage of ROS-producing PMNLs and the intensity of phagocytosis by PMNLs did not differ between treatment groups. Administration of the injectable ADE combination improved the percentage of weight gain between 20 and 40 days of age, decreased oxidative stress at 60 days of age and did not influence the function of PMNLs in piglets.

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