Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx

Revista do Colégio Brasileiro de Cirurgiões

Celso Muller Bandeira¹  Adriana Ávila De Almeida¹  Antonio José Gonçalves¹ 

关键词: Cytochrome P-450;    Genetic polymorphism;    Neoplasms of the head and neck.;    Sistema enzimático do citocromo P-450;    Polimorfismo genético;    Neoplasias de cabeça e pescoço;   

DOI  :  10.1590/0100-69912014005012

来源: SciELO

【 摘 要 】

Objective:To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx.Methods: We present a narrative literature review, conducted in Pubmed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk in different populations worldwide.Results: We initially found 65 articles and, after selection criteria, 20 case-control studies with various populations worldwide were eligible. The most studied polymorphisms were those of CYP2E1 and CYP1A1 subfamilies. There is little about the other subfamilies. The association found between polymorphisms and cancer risk amounted to a countless number of variables, amongst them: population, selection methods, racial factors and different modes of exposure to carcinogens, genotyping methods, and nomenclature of the polymorphisms.Conclusion: so far, there is no proven link between genetic polymorphisms of cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx relationship.

【 授权许可】

CC BY   
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