Polycystic ovary syndrome: implications of metabolic dysfunction

Revista do Colégio Brasileiro de Cirurgiões

Márcio Augusto Pinto De Ávila¹  Ricardo Vasconcellos Bruno¹  Fábio Cuiabano Barbosa¹  Felipe Cupertino De Andrade¹  Adriana Cardoso De Oliveira E Silva¹  Antonio Egídio Nardi¹ 

关键词: Polycystic ovary syndrome;    Metabolism;    Acanthosis nigricans;    Insulin resistance;    Prevalence;    Síndrome do ovário policístico;    Metabolismo;    Acantose nigricans;    Resistência à insulina;    Prevalência;   

DOI  :  10.1590/S0100-69912014000200006

来源: SciELO

【 摘 要 】

OBJECTIVE: To determine the prevalence of metabolic syndrome (MS) and its clinical interrelations in polycystic ovary syndrome (PCOS).METHODS: This was a cross-sectional, prospective study with 100 patients with diagnosed PCOS based on the consensus of Rotterdam (2003). We investigated the interrelationships of MS, with intrinsic PCOS data. Dermatological profile was analyzed, in addition to acanthosis nigricans (AN) in the presence of hirsutism and acne. The use of HOMA-IR (homeostatic model assessment of insulin resistance) aimed at the correlation with MS in order to establish the metabolic dysfunction with the state of insulin resistance.RESULTS: The mean and standard deviations corresponding figures for age, body mass index and waist circumference were, respectively, 25.72 (± 4.87), 30.63 (± 9.31) and 92.09 (± 18.73). The prevalence of MS was 36% and significantly correlated with BMI, AN, and in 51% of patients the state of insulin resistance (HOMA-IR). Regarding skin profile, only AN significant correlation with MS.CONCLUSION: We propose the routine inspection of metabolic components related to severe PCOS. These parameters configure the cardiovascular risk and such conduct is of undoubted importance to public health.

【 授权许可】

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