In vitro effect of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+, K+-ATPase

Química Nova

Anne Caroline Candido Gomes²  Luzia Da Silva Sampaio¹  Paulo André Da Silva¹  Marcelo Einicker Lamas¹  Cassia Mônica Sakuragui¹  Cleber Bomfim Barreto Junior¹  Naomi Kato Simas¹  Ricardo Machado Kuster² 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Pesquisas de Produtos Naturais Rio de Janeiro RJ ,Brasil

关键词: Syngonium podophyllum;    Araceae;    Isoschaftoside;    enzyme inhibition;    renal Na+;    K+-ATPase;   

DOI  :  10.5935/0100-4042.20140257

来源: SciELO

【 摘 要 】

The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significantly decreased the renal Na+, K+-ATPase activity at the highest concentration as well as at a lower concentration. Our work suggests that isoschaftoside is a promising compound for the treatment of hypertension.

【 授权许可】

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