In vitro effect of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+, K+-ATPase

Química Nova

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Kuster, Ricardo Machado¹  Sampaio, Luzia da Silva¹  Simas, Naomi Kato¹  Barreto Junior, Cleber Bomfim¹  Gomes, Anne Caroline Candido¹  Silva, Paulo André da¹  Lamas, Marcelo Einicker¹  Sakuragui, Cassia Mônica¹  Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Rio de Janeiro, Brasil¹ 

关键词: Syngonium podophyllum;    Araceae;    Isoschaftoside;    enzyme inhibition;    renal Na+;    K+-ATPase.;   

DOI  :  10.5935/0100-4042.20140257

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significantly decreased the renal Na+, K+-ATPase activity at the highest concentration as well as at a lower concentration. Our work suggests that isoschaftoside is a promising compound for the treatment of hypertension.

【 授权许可】

Unknown