Síntese da fenitoína assistida por micro-ondas: proposta de aula prática para alunos de graduação

Química Nova

Eduardo L. Konrath¹  Maristela Piedade¹  Vera Lucia Eifler-lima¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Departamento de Produção de Matéria-Prima

关键词: drug synthesis;    phenytoin;    microwave-assisted organic synthesis;   

DOI  :  10.1590/S0100-40422012000900033

来源: SciELO

【 摘 要 】

Microwave synthesis is considered a breakthrough in the field of chemistry due to its benefits over conventional heating methods. We describe, for the first time, the total synthesis of phenytoin adapted for a microwave reactor, proposed as an experiment for undergraduate courses. When carried out with microwaves, the synthetic route provided phenytoin in 6 min and 30 s, while for conventional heating the total time was 170 min. The experiment also involves rapid identification of compounds by TLC, ¹H NMR, FT-IR and melting points determination.

【 授权许可】

CC BY-NC   
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