Microwave-assisted phenytoin synthesis: proposed practical class for undergraduate students

Química Nova

Eifler-Lima, Vera Lucia¹  Konrath, Eduardo L.¹  Piedade, Maristela¹  Universidade Federal do Rio Grande do Sul¹ 

关键词: drug synthesis;    phenytoin;    microwave-assisted organic synthesis.;   

DOI  :  10.1590/S0100-40422012000900033

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Microwave synthesis is considered a breakthrough in the field of chemistry due to its benefits over conventional heating methods. We describe, for the first time, the total synthesis of phenytoin adapted for a microwave reactor, proposed as an experiment for undergraduate courses. When carried out with microwaves, the synthetic route provided phenytoin in 6 min and 30 s, while for conventional heating the total time was 170 min. The experiment also involves rapid identification of compounds by TLC, 1H NMR, FT-IR and melting points determination.

【 授权许可】

Unknown