Desenvolvimento e caracterização de nanopartículas lipídicas destinadas à aplicação tópica de dapsona

Química Nova

Guilherme Soares Dos Santos²  Gabriela Garrastazu Pereira²  Eduardo André Bender²  Letícia Marques Colomé²  Sílvia Stanisçuaski Guterres²  Daniel Canema Manhães De Carvalho¹  Gilberto Weissmüller¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Porto Alegre RS ,Brasil

关键词: lipid nanoparticles;    dapsone;    in vitro release study;   

DOI  :  10.1590/S0100-40422012000700019

来源: SciELO

【 摘 要 】

In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).

【 授权许可】

CC BY-NC   
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