Development and characterization of lipid nanoparticles for dapsone topical application

Quimica nova

Santos, Guilherme Soares dos¹  Pereira, Gabriela Garrastazu¹  Colomé, Letícia Marques¹  Guterres, Sílvia Stanisçuaski¹  Bender, Eduardo André¹  Weissmüller, Gilberto²  Carvalho, Daniel Canema Manhães de² 

[1] Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: lipid nanoparticles;    dapsone;    in vitro release study.;   

DOI  :  10.1590/S0100-40422012000700019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).

【 授权许可】

CC BY