Desenvolvimento e validação de método analítico para a determinação de sulfassalazina em suspensão oral: comparação do método espectrofotométrico e de cromatografia líquida de alta eficiência (CLAE)

Química Nova

Mayre Aparecida Borges Da Costa²  Eduardo Ricci-júnior²  Elisabete Pereira Dos Santos²  Claudia Regina Elias Mansur¹  Vânia Emerich Bucco De Campos¹ 

[1] ,Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Faculdade de FarmáciaRio de Janeiro RJ ,Brasil

关键词: sulfasalazine;    oral suspension;    analytical method;   

DOI  :  10.1590/S0100-40422012000400028

来源: SciELO

【 摘 要 】

Sulfasalazine is a prodrug used in the treatment of the Chron's disease and rheumatoid arthritis. Two analytical methods for analysis of sulfasalazine in oral suspension were validated using Spectrophotometric and HPLC. There is not any pharmacopoeic method to assay sulfasalazine in oral suspension. The methods are insurance and fast execution for the quality control. Both, suspension and tablets 500 mg (Azulfin®) had been analyzed by methods using UV/VIS and HPLC and the results were satisfactory.

【 授权许可】

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