Development and validation of analytical method for determination of sulfasalazine in oral suspension: comparasion between spectroscopic and high performance liquid chromathography

Quimica nova

Santos, Elisabete Pereira dos¹  Mansur, Claudia Regina Elias¹  Ricci-Júnior, Eduardo¹  Campos, Vânia Emerich Bucco de¹  Costa, Mayre Aparecida Borges da¹ 

[1] Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: sulfasalazine;    oral suspension;    analytical method.;   

DOI  :  10.1590/S0100-40422012000400028

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Sulfasalazine is a prodrug used in the treatment of the Chron's disease and rheumatoid arthritis. Two analytical methods for analysis of sulfasalazine in oral suspension were validated using Spectrophotometric and HPLC. There is not any pharmacopoeic method to assay sulfasalazine in oral suspension. The methods are insurance and fast execution for the quality control. Both, suspension and tablets 500 mg (Azulfin®) had been analyzed by methods using UV/VIS and HPLC and the results were satisfactory.

【 授权许可】

CC BY