Validação de método espectrofotométrico na região do UV para quantificação de famotidina em cápsulas

Química Nova

Lívia Botacini Favoretto¹  Juliana Maria Oliveira Souza¹  Rudy Bonfilio¹  Roberta De Cássia Pimentel Azevedo¹  Magali Benjamim De Araújo¹ 

[1] ,Universidade Federal de Alfenas Departamento de Farmácia Alfenas MG ,Brasil

关键词: famotidine;    validation;    UV spectrophotometry;   

DOI  :  10.1590/S0100-40422010000700028

来源: SciELO

【 摘 要 】

This work describes the validation of a method for quantification of famotidine in capsules by UV spectrophotometry using as solvents buffer solution at pH 2.5 and buffer solution at pH 4.5. The results show that the method is practical, selective, accurate, precise and linear from 10.0 to 25.0 µg/mL of famotidine in both solvents. However, a variance analysis showed a lower mean percentage of famotidine when buffer at pH 2.5 is used. This effect was attributed to the instability of famotidine in acidic media. Therefore, the use of pH 4.5 buffer was considered suitable for analysis of famotidine in capsules.

【 授权许可】

CC BY-NC   
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