Determinação espectrofotométrica de cefalexina em formulações farmacêuticas explorando a sua reação de transferência de carga com a quinalizarina

Química Nova

Carlos Eduardo R. De Paula¹  Vanessa G. K. Almeida¹  Ricardo J. Cassella¹ 

[1] ,Universidade Federal Fluminense Departamento de Química Analítica Niterói RJ ,Brasil

关键词: cephalexin;    charge transfer reaction;    spectrophotometry;   

DOI  :  10.1590/S0100-40422010000400029

来源: SciELO

【 摘 要 】

This work proposes a new simple and fast spectrophotometric method for cephalexin determination in pharmaceutical formulations. The method is based on the charge transfer reaction between cephalexin and quinalizarin in dimethylsulfoxide medium. Several analytical parameters related to the system were optimized and the reaction was characterized in terms of stoichiometry. Also, association constant and apparent molar absorptivity of the product were determined. The method presented a limit of detection of 0.46 mg L-1 and a quantification limit of 1.5 mg L-1. It was successfully applied in the determination of cephalexin in two samples of commercial pharmaceutical formulations.

【 授权许可】

CC BY-NC   
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