Spectrophotometric determination of cephalexin in pharmaceutical formulations exploring its charge transfer reaction with quinalizarin

Química Nova

Universidade Federal Fluminense, Niterói, Brasil¹  Cassella, Ricardo J.¹  Paula, Carlos Eduardo R. de¹  Almeida, Vanessa G. K.¹ 

关键词: cephalexin;    charge transfer reaction;    spectrophotometry.;   

DOI  :  10.1590/S0100-40422010000400029

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work proposes a new simple and fast spectrophotometric method for cephalexin determination in pharmaceutical formulations. The method is based on the charge transfer reaction between cephalexin and quinalizarin in dimethylsulfoxide medium. Several analytical parameters related to the system were optimized and the reaction was characterized in terms of stoichiometry. Also, association constant and apparent molar absorptivity of the product were determined. The method presented a limit of detection of 0.46 mg L-1 and a quantification limit of 1.5 mg L-1. It was successfully applied in the determination of cephalexin in two samples of commercial pharmaceutical formulations.

【 授权许可】

Unknown