Tetraciclinas e glicilciclinas: uma visão geral

Química Nova

Elene Cristina Pereira-maia¹  Priscila Pereira Silva¹  Wagner Batista De Almeida¹  Hélio Ferreira Dos Santos²  Bruna Luana Marcial²  Reinaldo Ruggiero²  Wendell Guerra² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Exatas Departamento de QuímicaBelo Horizonte MG ,Brasil

关键词: tetracyclines;    glycylcyclines;    antibacterial activity;   

DOI  :  10.1590/S0100-40422010000300038

来源: SciELO

【 摘 要 】

Tetracyclines exhibits activity to a broad range of Gram-negative and Gram-positive bacteria and this fact allied to the low toxicity, low cost, and the advantage of administration by oral route led to their indiscriminate use, which caused the appearance of bacterial resistance to these agents, wich has restricted its clinical utility, though new applications have emerged. On the other hand, the glycylcyclines, semi-synthetic products are similar to tetracyclines, which are active against many bacteria resistant to tetracycline and other classes of antibiotics. The purpose of this paper is to give an overview of this important class of antibiotics focusing on its coordination chemistry and possible applications.

【 授权许可】

CC BY-NC   
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