Tetracyclines and glycylcyclines: an overview

Química Nova

Silva, Priscila Pereira¹  Universidade Federal de Uberlândia, Uberlândia, Brasil¹  Pereira-Maia, Elene Cristina¹  Ruggiero, Reinaldo¹  Almeida, Wagner Batista de¹  Marcial, Bruna Luana¹  Santos, Hélio Ferreira dos¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil¹  Guerra, Wendell¹ 

关键词: tetracyclines;    glycylcyclines;    antibacterial activity.;   

DOI  :  10.1590/S0100-40422010000300038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Tetracyclines exhibits activity to a broad range of Gram-negative and Gram-positive bacteria and this fact allied to the low toxicity, low cost, and the advantage of administration by oral route led to their indiscriminate use, which caused the appearance of bacterial resistance to these agents, wich has restricted its clinical utility, though new applications have emerged. On the other hand, the glycylcyclines, semi-synthetic products are similar to tetracyclines, which are active against many bacteria resistant to tetracycline and other classes of antibiotics. The purpose of this paper is to give an overview of this important class of antibiotics focusing on its coordination chemistry and possible applications.

【 授权许可】

Unknown