Síntese de β-D-galactopiranosídeos de arila diméricos para avaliação de sua interação com a lectina de Erythrina cristagalli

Química Nova

Rute Cunha Figueiredo²  Nádia Burkowski Meyer²  Maria Auxiliadôra Fontes Prado²  Ricardo José Alves²  Javier Rojo¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Produtos FarmacêuticosBelo Horizonte MG ,Brasil

关键词: D-galactopyranose;    glycodendrimers;    Erythrina cristagalli;   

DOI  :  10.1590/S0100-40422009000800026

来源: SciELO

【 摘 要 】

The synthesis of two new D-galactose-based dimers having a 1,4-butanediamine spacer is reported aiming at the evaluation of their interaction with the Erythrina cristagalli lectin. The title compounds were prepared in four and five steps from 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside bromide, in 20 % and 15 % overall yield, respectively, using the Doebner modification of the Koenavenagel reaction as the key sep. The lectin-carbohydrate interaction could be evaluated for only one dimer, due to solubility problems. A twofold enhancement of affinity was observed, compared to the corresponding monovalent ligand.

【 授权许可】

CC BY-NC   
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