Synthesis of dimeric aryl β-D-galactopyranosides for the evaluation of their interaction with the Erythrina cristagalli lectin

Química Nova

Meyer, Nádia Burkowski¹  Alves, Ricardo José¹  Figueiredo, Rute Cunha¹  Rojo, Javier¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Prado, Maria Auxiliadôra Fontes¹  Instituto de Investigaciones Químicas, Sevilla, Espanha¹ 

关键词: D-galactopyranose;    glycodendrimers;    Erythrina cristagalli.;   

DOI  :  10.1590/S0100-40422009000800026

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The synthesis of two new D-galactose-based dimers having a 1,4-butanediamine spacer is reported aiming at the evaluation of their interaction with the Erythrina cristagalli lectin. The title compounds were prepared in four and five steps from 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside bromide, in 20 % and 15 % overall yield, respectively, using the Doebner modification of the Koenavenagel reaction as the

【 授权许可】

Unknown