Atividade antibacteriana de floroglucinóis e do extrato hexânico de Hypericum brasiliense Choysi

Química Nova

Hildegardo Seibert França²  Ricardo Machado Kuster²  Priscila Da Nóbrega Rito¹  Adriana Passos De Oliveira¹  Lenise Arneiro Teixeira¹  Leandro Rocha¹ 

[1] ,Universidade Federal do Rio de Janeiro Núcleo de Pesquisa de Produtos Naturais Rio de Janeiro RJ ,Brasil

关键词: Hypericum brasiliense;    antibacterial activity;    phloroglucinol;   

DOI  :  10.1590/S0100-40422009000500004

来源: SciELO

【 摘 要 】

Three phloroglucinols were obtained from Hypericum brasiliense: japonicine A (1), isouliginosin B (2) and uliginosin B (3). Bioautography and disk diffusion methods were used to determine antibacterial activity of the hexanic extract. Strains of the Coagulase Negative Staphylococcus and American Methicillin Resistant Staphylococcus aureus clones showed a growth inhibition zone ranging from 10 to 12 mm and 7 to 15 mm, respectively. Minimal inhibitory concentration (MIC) values were used to measure antistaphylococcal activity for all phloroglucinols. Isouliginosin B and uliginosin B presented MIC values of 1.5 and 3.0 µg/mL, respectively, while japonicine A displayed MIC value of 50.0 µg/mL.

【 授权许可】

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