Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas

Química Nova

Ana Luiza Maurer Da Silva²  José Lamartine Soares Sobrinho²  Pedro José Rolim Neto²  Rosali Maria Ferreira Da Silva¹  Flávia Patrícia Morais De Medeiros¹  Leduar Guedes De Lima¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Ciências Farmacêuticas Recife PE ,Brasil

关键词: development of method;    validation;    high performance liquid chromatography;   

DOI  :  10.1590/S0100-40422007000500021

来源: SciELO

【 摘 要 】

The analytical method of high performance liquid chromatography (HPLC) for the assay of benznidazole in tablets was developed and validated following the requirements of regulatory agencies. The method used as mobile phase acetonitrile:wather 1:1, a C18 column of 12.5 cm length x 4 mm id, 5 mm particles and lambda=316 nm. The statistical analysis of the results demonstrated that the method satisfies all parameters so as to be considered a safe and efficient analytical alternative of low cost for laboratory routine.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License