Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease

Química Nova

Laboratório Farmacêutico do Estado de Pernambuco, Recife, Brasil¹  Silva, Rosali Maria Ferreira da¹  Medeiros, Flávia Patrícia Morais de¹  Lima, Leduar Guedes de¹  Soares Sobrinho, José Lamartine¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Silva, Ana Luiza Maurer da¹  Rolim Neto, Pedro José¹ 

关键词: development of method;    validation;    high performance liquid chromatography.;   

DOI  :  10.1590/S0100-40422007000500021

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The analytical method of high performance liquid chromatography (HPLC) for the assay of benznidazole in tablets was developed and validated following the requirements of regulatory agencies. The method used as mobile phase acetonitrile:wather 1:1, a C18 column of 12.5 cm length x 4 mm id, 5 mm particles and l=316 nm. The statistical analysis of the results demonstrated that the method satisfies all parameters so as to be considered a safe and efficient analytical alternative of low cost for laboratory routine.

【 授权许可】

Unknown