Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?

Química Nova

Lívea Fujita Barbosa¹  Marisa H.g. De Medeiros¹  Ohara Augusto¹ 

[1] ,Universidade de São Paulo Instituto de Química Departamento de BioquímicaSão Paulo SP

关键词: oxidative damage;    neurodegeneration;    transgenic;    knockout mice;   

DOI  :  10.1590/S0100-40422006000600034

来源: SciELO

【 摘 要 】

Accumulated evidence indicates that oxidative stress plays a role in neurodegenerative diseases, such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis. Here, we emphasize the results provided by the technology of genetically modified animals. Studies with transgenic and knockout mice have allowed great advances in the research of oxidative stress in general and in the central nervous system, and are pointing to potential targets for the development of new drugs and therapies to disrupt the cycle of events that lead to neuronal death. Thus, genetically modified animals are a valuable tool for the comprehension of human diseases, including neurodegenerative ones.

【 授权许可】

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