New antagonist agents of neuropeptide y receptors

Química Nova

Ignacio Aldana²  Isabel Rivero²  Argimiro Rivero²  Patricio Huenchuñir²  Carmen Frigola²  Maria Luisa Alonso²  Antonio Monge²  D. H. Caignard¹  P. Renard¹ 

[1] ,University of Navarra CIFA Department of Pharmaceutical Chemistry,Spain

关键词: obesity;    energy metabolism;    weight reduction;    neuropeptide Y;   

DOI  :  10.1590/S0100-40422000000600005

来源: SciELO

【 摘 要 】

In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.

【 授权许可】

CC BY-NC   
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