Utilização de endoperóxidos de derivados de naftaleno como fontes químicas de oxigênio singlete em sistemas biológicos

Química Nova

Glaucia R. Martinez¹  Marisa H. G. Medeiros¹  Paolo Di Mascio¹ 

[1] ,Universidade de São Paulo Instituto de Química Departamento de BioquímicaSão Paulo SP

关键词: singlet oxygen;    naphthalene endoperoxides;    biological systems;   

DOI  :  10.1590/S0100-40422000000500018

来源: SciELO

【 摘 要 】

Molecular oxygen, in the first excited state (singlet oxygen, ¹O2), has a substantial reactivity towards electron-rich organic molecules, such as biological targets, including unsaturated fatty acids, proteins, RNA and DNA. Considering the complexity of biological systems and the great variety of reactive species generated by photochemistry, efforts have been devoted to develop suitable ¹O2 generators based on the thermolysis of water soluble naphthalene endoperoxides. These compounds are chemically inert and have been employed as versatile sources of ¹O2. The synthesis is based on structural modifications in position 1,4 of dimethylnaphtalene, grafting hydrophilic substituents. The correspondent endoperoxide can be generated using photochemical method, or molybdate-catalyzed disproportionation of hydrogen peroxide.

【 授权许可】

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