Estudo da influência da natureza de reticulantes e aditivos orgânicos sobre o comportamento de géis de quitosana

Química Nova

Marconi F. Ginani¹  Marco V. Navarro¹  Ednaldo G. Do Nascimento¹  Uazir O. B. De Oliveira¹ 

[1] ,Universidade Federal do Rio Grande do Norte Departamento de Química Natal RN

关键词: chitosan;    gel;    polysaccharide;   

DOI  :  10.1590/S0100-40421999000600005

来源: SciELO

【 摘 要 】

The physical-chemical process of swelling in water-based gel of natural polymers is investigated with the purpose of applying these systems to biomedical materials for controlled release of drugs. In this work we develop a study about the sol-gel transition of solutions of chitosan in the presence of formaldehyde and glutaraldehyde like crosslinking agents and we have determined the effect of many aditives in the time of gelification from the elaborated sistems. The phisical-chemistry process of swelling of the formed gels was evaluated in function of the degree of crosslinking of the incorporated aditives and the pH. Gelling times of chitosan solutions were obtained using viscosimetric measurement, in the pre-gel state, as well as condutivity ones.The results obtained suggest that component concentration modifies the kinetic profile of the transition and the swelling behavior. Regarding H+ content, the gels were highly susceptible to swelling in acidic conditions, which characterize this system as pH - sensitive.

【 授权许可】

CC BY-NC   
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