Síntese e atividade citotóxica de alguns azido-ciclopaladados estabilizados com ligantes bifosfínicos

Química Nova

Antonio Carlos Fávero Caires²  Eduardo T. Almeida¹  Antonio E. Mauro¹  Jefferson P. Hemerly¹  Sandro R. Valentini¹ 

[1] ,Universidade de Mogi das CruzesMogi das Cruzes SP

关键词: azido-cyclopalladated compounds;    antitumour agents;    palladium (II) complexes;   

DOI  :  10.1590/S0100-40421999000300008

来源: SciELO

【 摘 要 】

Some cyclopalladated compounds containing the azido group ligand and the (C-N) ring of N,N-dimethylbenzylamine have been prepared by bridge opening reactions of dimmer azide complex precursor with some diphosphines in different stoichiometric quantities. The neutral or ionic, mono or binuclear complexes synthesized were characterized by elemental analyses, I. R. spectroscopy and NMR techniques. The series of complexes was screened for cytotoxicity against a panel three human tumour cells lines(C6,Hep-2,HeLa). All complexes were found to be cytotoxic (IC50) at µM concentrations while one complex having the coordination bond N-Pd ruptured also displayed some differential cytotoxicity.

【 授权许可】

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